Motor Proteins: Tightening Your Belt with Myosin VI
نویسندگان
چکیده
New work shows that the motor protein myosin VI, acting through vinculin, plays a key role in the maturation of cadherin-based adherens junctions in epithelial cells.
منابع مشابه
Multifunctional myosin VI has a multitude of cargoes.
I n humans, a vast array of cytoskeletal motor proteins (19 dyneins, 43 kinesins, and 39 myosins) (1) move along microtubule and actin filament tracks to generate an enormous range of cellular functions. The kinesin and dynein motor proteins drive long-distance transport along microtubules, whereas the myosins are responsible for short-range delivery along actin filaments (2). The myosin motor ...
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Myosins of class VI are unique actin based motor proteins that move cargo towards the minus ends of actin filaments. This motor interacts with a wide variety of adaptor proteins, which regulate cargo attachment and thus mediate the very specific intracellular functions of myosin VI in the endocytic and exocytic membrane trafficking pathways. These adaptor proteins may also act as molecular swit...
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In neurons polarized trafficking of vesicle-bound membrane proteins gives rise to the distinct molecular composition and functional properties of axons and dendrites. Despite their central role in shaping neuronal form and function, surprisingly little is known about the molecular processes that mediate polarized targeting of neuronal proteins. Recently, the plus-end-directed motor Myosin Va wa...
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Actin is found at the cortex of the cell where endocytosis occurs, but does it play a role in this essential process? Recent studies on the unconventional myosin, myosin VI, an actin-based molecular motor, provide compelling evidence that this myosin and therefore actin is involved in two distinct steps of endocytosis in higher eukaryotes: the formation of clathrin-coated vesicles and the movem...
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Mutations in myosin VI have been associated with autosomal-recessive (DFNB37) and autosomal-dominant (DFNA22) deafness in humans. Here, we characterise an myosin VI nonsense mutation (R1166X) that was identified in a family with hereditary hearing loss in Pakistan. This mutation leads to the deletion of the C-terminal 120 amino acids of the myosin VI cargo-binding domain, which includes the WWY...
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عنوان ژورنال:
- Current Biology
دوره 17 شماره
صفحات -
تاریخ انتشار 2007